I have serious dry mouth from medication side effects. I've used Biotene for the last 20 years at my doctor's suggestion. Her husband was a dentist. I've never used any other toothpaste since. It's great for my condition but it can only give temporary relief as any toothpaste can. I also use Biotene mouthwash. Again, great for me but also temporary but longer than the toothpaste. Lastly, I also use the smaller tube of Biotene paste for instant relief. Biotene cannot cure drymouth but it is the absolute best relief on the market. I couldn't be without it.